Spinal Cord Injury Neuroprotection With Glyburide

Drug
General health
Online since 2 November 2021, updated 889 days ago

About this trial

This trial is enrolling individuals with new spinal cord injuries to the cervical (neck) area to test a drug, Glyburide. This drug is approved for use in other diseases, e.g., diabetes type 2. Researchers want to see if the drug is safe and whether it has a protective effect on the nervous system. This trial will also measure effect of this drug on improving neurological recovery. This is an open-label study — all participants will receive the drug and there is no control (comparison) group. Participants will receive the drug (by mouth) within 8 hours of injury, for 3 days. Follow up will occur at days 28, 42, 84, 182 and 365.

Included participants

Gender
All
Age
18 - 80 years
Injury level
C2 - C8
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≤ 8 hours
  • Injury type
  • Traumatic

    Healthy volunteers
    No
    C2-C8
    Additionally, participants must
    NOT have penetrating injury, e.g. gunshot to knife wound

    What’s involved

    Type

    Drug

    Details

    Admission at the study site to take the drug within 8 hours of injury. Taking the drug by mouth every 6 hours for 3 days. Starting on admission into the study, study testing and/or data collection will be done until discharge and on Days 14, 28, 42, 84, 182, and 365.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Sensory function

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Ended
    • Trial start date
    • 14 Feb 2017
    • Organisation
    • Ohio State University
    • Trial recruitment status
    • Ended
    • Trial start date
    • 14 Feb 2017
    • Organisation
    • Ohio State University

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more