Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury

Surgery
General health
Online since 2 November 2021, updated 897 days ago

About this trial

This trial is recruiting individuals with acute cervical spinal cord injuries to test whether draining cerebrospinal fluid from around the spinal cord in combination with a drug to boost blood pressure will increase recovery. The hypothesis is that regulating blood pressure will result in less cell death and nerve cell damage, leading to an improvement in neurological function. Participants will receive a norepinephrine drug to raise mean arterial pressure (average blood pressure) along with spinal fluid drainage, or drug without spinal fluid drainage. Participants will have neurological exams at 3 days, 3 months, and 6 months after treatment.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C4 - C8
  • Severity (AIS)?
  • AIS-A
    AIS-B
    AIS-C
    Time since injury
    ≤ 24 hours
  • Injury type
  • Traumatic

    Non-traumatic

    Healthy volunteers
    No
    C4-C8
    Additionally, participants must
    NOT have penetrating injury, e.g. gunshot or knife wound

    What’s involved

    Type

    Surgery

    Details

    The participant will receive a drug to raise mean arterial pressure (MAP; average blood pressure in the arteries) for 5 days, in combination with or without draining some fluid from around their spine. Neurological exam 3 days, 3 months, and 6 months after the intervention.

    Potential benefits

    Main benefits

    General health

    Additional benefits

    Arm/hand function

    Pain

    Sensory function

    Standing/walking/mobility

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Ended
    • Trial start date
    • 1 Oct 2015
    • Organisation
    • St. Joseph's Hospital and Medical Center, Phoenix
    • Trial recruitment status
    • Ended
    • Trial start date
    • 1 Oct 2015
    • Organisation
    • St. Joseph's Hospital and Medical Center, Phoenix

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more