Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury

Drug
Standing/walking/mobility
Online since 1 November 2021, updated 494 days ago

About this trial

This trial is recruiting individuals with incomplete spinal cord injuries to test the effect of breathing air with low oxygen (acute intermittent hypoxia) in combination with caffeine to improve leg function. Participants will swallow capsules containing either caffeine or sugar (placebo). Each will receive both caffeine and sugar capsules, but the order of the capsules will not be known. After 1 hour participants will breathe short periods of low oxygen air through a face mask, alternating with room air. Following the breathing session, saliva will be tested for the amount of caffeine in the body. After each treatment (caffeine or placebo), walking speed and leg strength will be assessed

Included participants

Gender
All
Age
18 - 75 years
Injury level
C2 - T11
  • Severity (AIS)?
  • AIS-C
    AIS-D
    Time since injury
    1 year - 75 years
  • Injury type
  • Traumatic

    Non-traumatic

    Ischemia

    Healthy volunteers
    Yes
    C2-T11

    What’s involved

    Type

    Drug

    Details

    The participant will take a capsule containing caffeine for one interventional session, and sugar (placebo) for the second session. After 1 hour, the participant will breathe air with low oxygen through a face mask. The participant will be asked to spit into a small container before and after each breathing session. The participant will be tested for walking speed and leg strength after each session.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Recruitment
    • Unknown
    • Trial start date
    • 1 Jan 2019
    • Organisation
    • Spaulding Rehabilitation Hospital
    • Recruitment
    • Unknown
    • Trial start date
    • 1 Jan 2019
    • Organisation
    • Spaulding Rehabilitation Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more