Acute Intermittent Hypoxia on Leg Function Following Spinal Cord Injury

Drug
Standing/walking/mobility
Online since 1 November 2021, updated 689 days ago

About this trial

This study is recruiting people with chronic incomplete spinal cord injuries to test how breathing air with low oxygen alternated with normal room air (acute intermittent hypoxia; AIH) improves leg function. Repetitive exposure to mild hypoxia may have benefits for spinal cord recovery, including protein synthesis and modified nerve circuitry to improve breathing, leg strength and walking. Participants will either breathe short periods of low oxygen or room air, through a face mask, 3 times per week; neither participant nor investigator will know the order of the treatments. After each treatment, testing will assess walking and leg strength, and safety.

Included participants

Gender
All
Age
18 - 75 years
Injury level
C4 - T12
  • Severity (AIS)?
  • AIS-C
    AIS-D
    Time since injury
    1 year - 75 years
  • Injury type
  • Traumatic

    Non-traumatic

    Ischemia

    Healthy volunteers
    No
    C4-T12

    What’s involved

    Type

    Drug

    Details

    For the first 2 weeks: 5 sessions a week of 38 minutes of either 1) repeatedly breathing air with low oxygen content for brief periods, alternating with breathing room air with normal oxygen content (AIH) or 2) sham AIH. For the next 2 weeks: 5 sessions a week of 38 minutes of either 1) repeatedly breathing air with low oxygen content for brief periods, alternating with breathing room air with normal oxygen content (AIH) or 2) sham AIH (depending on what they receive in the previous weeks). Tests for walking endurance and speed after 5 days, and 1, 2, and 4 weeks after each intervention.

    Potential benefits

    Main benefits

    Standing/walking/mobility

    Additional benefits

    General health

    Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more

    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Oct 2014
    • Organisation
    • Spaulding Rehabilitation Hospital
    • Trial recruitment status
    • Recruiting
    • Trial start date
    • 1 Oct 2014
    • Organisation
    • Spaulding Rehabilitation Hospital

    Wings for Life supports SCITrialsFinder

    Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

    Learn more