Mean Arterial Blood Pressure Treatment for Acute Spinal Cord Injury

Drug

Arm/hand function

Online since 1 November 2021, updated 898 days ago

About this trial

This study is recruiting individuals with acute spinal cord injuries to evaluate the effect of medical management of blood pressure on motor function, sensory function, and quality of life. Participants will either receive treatment to produce slightly higher blood pressure (hypertension), or will be maintained at normal blood pressure for 7 days after injury. The study hypothesis is that inducing higher blood pressure, which is the current clinical practice, does not offer significant benefits to patients when compared to normal blood pressure maintenance.

Included participants

Gender

All

Age

≥ 16 years

Injury level

C1 - T12

Severity (AIS)?

AIS-A

AIS-B

AIS-C

Time since injury

≤ 24 hours

Injury type

Traumatic

Healthy volunteers

C1-T12

What’s involved

Type

Drug

Details

The participant will either get medical management to 1) maintain their blood pressure at >=65mmHg or 2) produce slightly higher blood pressure (>=85mmHg) for 7 days after their injury. Neurological examination (ASIA exam) 12 months after the injury.

Potential benefits

Main benefits

Arm/hand function

Additional benefits

General health

Mental health and psychosocial factors

Sensory function

Standing/walking/mobility

Good to know: Potential benefits are defined as outcomes that are being measured during and/or after the trial.

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Wings for Life has proudly initiated, led and funded the new version of the SCI Trials Finder website. Wings for Life aims to find a cure for spinal cord injuries. The not-for-profit foundation funds world-class scientific research and clinical trials around the globe.

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