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    "result": {"pageContext":{"pagePath":"/trials/NCT07412808","trial":{"nct_id":"NCT07412808","brief_title":"Spinal Cord Stimulation Combined With Motor Training in Non-Traumatic SCI: A Prospective Interventional Study","official_title":"Evaluation of Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function in Non-traumatic Spinal Cord Injury: an Interventional, Prospective, Monocentric Study","about_trial":"This trial is enrolling 10 participants with chronic non-traumatic spinal cord injury to test the effect of epidural spinal stimulation (eSS) combined with walking training on lower extremity function. eSS is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. If included, participants will undergo surgical implantation of an eSS device followed by a structured rehabilitation program, including intensive standing and stepping training. Final testing of lower extremity function will be performed after 6 months.","age_from":18,"age_to":null,"ais_a":true,"ais_b":true,"ais_c":true,"ais_d":false,"ais_e":false,"time_since_injury_from":12,"time_since_injury_from_unit":"months","time_since_injury_to":null,"time_since_injury_to_unit":null,"healthy_volunteers":false,"inclusion_criteria":null,"study_type":"interventional","allocation":"N/A","brief_description":"Interventional prospective longitudinal on the evaluation of spinal cord stimulation (SCS) assisted by motor rehabilitation training for restoring motor function in patients with non-traumatic spinal cord injury (SCI). The investigators will enroll ten research participants with clinically incomplete/complete SCI (patients with paraplegia or severe paraparesis) who will undergo SCS subsequently assisted by motor rehabilitation training for restoring motor function at IRCCS Ospedale San Raffaele, Milan, Italy. The main goal of the project is to evaluate the improvement in motor function generated by the combination of SCS and locomotor training. In line with recently published studies, the investigators propose that daily locomotor training in the presence of SCS with continuous stimulation parameters setting will enable the SCI individuals to stand and step independently while bearing full weight.","detailed_description":"- Participants will undergo surgical implantation of an epidural spinal stimulation (eSS) device followed by a structured rehabilitation program, including intensive standing and stepping training.\n- eSS is an invasive technique that uses an implanted electrode placed next to the spinal cord to deliver electrical stimulation aimed at modifying spinal cord function. \n- Final testing of lower extremity function will be performed after 6 months.","final_testing_performed":"6 months","version_id":6,"emsci_trial":false,"curation_status":"curated","overall_recruitment_status":"recruiting-soon","primary_intervention":{"id":5,"name":"Technology","parent_id":null,"icon_name":"technology"},"primary_benefit":{"id":12,"name":"Standing/walking/mobility","parent_id":null,"icon_name":"walking"},"sex":"All","injury_level_from":"T1","injury_level_to":"S5","start_date":"2026-03","organization":"IRCCS San Raffaele","benefits":[{"id":5,"name":"General health","parent_id":null,"icon_name":"general-health"},{"id":7,"name":"Pain","parent_id":null,"icon_name":"pain-relief"},{"id":11,"name":"Spasticity","parent_id":null,"icon_name":"wave"},{"id":12,"name":"Standing/walking/mobility","parent_id":null,"icon_name":"walking"}],"injuries":[{"id":6,"name":"Non-traumatic","parent_id":2,"pivot":{"trial_id":7994,"injury_id":6}}],"interventions":[{"id":3,"name":"Rehabilitation","parent_id":null,"icon_name":"medical-rehabilitation"},{"id":4,"name":"Surgery","parent_id":null,"icon_name":"scalpel"},{"id":5,"name":"Technology","parent_id":null,"icon_name":"technology"}],"outcome_measures":[{"id":9,"name":"Ashworth and Modified Ashworth Scale (MAS)","short_name":"MAS","pivot":{"trial_id":7994,"outcome_measure_id":9}},{"id":79,"name":"Magnetic Resonance Imaging (MRI) - conventional/anatomical and quantitative","short_name":"MRI","pivot":{"trial_id":7994,"outcome_measure_id":79}},{"id":201,"name":"McGill Pain Questionnaire","short_name":null,"pivot":{"trial_id":7994,"outcome_measure_id":201}},{"id":172,"name":"Motor Evoked Potentials (MEPs)","short_name":"MEPs","pivot":{"trial_id":7994,"outcome_measure_id":172}},{"id":202,"name":"Pain Catastrophizing Scale (PCS)","short_name":"PCS","pivot":{"trial_id":7994,"outcome_measure_id":202}},{"id":122,"name":"Sensory evoked potentials (including mixed and dermatomal, mSSEPs, dSSEPs, contact heat/laser evoked potentials- CHEPS/LEPs)","short_name":null,"pivot":{"trial_id":7994,"outcome_measure_id":122}}],"recovery_mechanisms":[],"published_at":"2026-04-26T04:04:05.000000Z","modified_at":"2026-04-26T04:04:05.000000Z"},"layout":"trial"}},
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